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Scientific Research

Evaluation of L-Carnitine Efficacy in the Treatment of Non-Alcoholic Fatty Liver Disease among Diabetic Patients: A Randomized Double Blind Pilot Study. Read More

Alpha-Lipoic Acid (ALA), fatty acid and promising chelating agent for neurological ailments. Read More

The Role of Thiamine in Wilson’s Disease: Possible Genetic and Cellular Signaling Mechanisms. Read More

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies. Read More

A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders. Read More

Salvatore S, Heuschkel R, Tomlin S, Davies SE, Edwards S, Walker-Smith JA, French I, Murch SH. A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease. Read More

Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Read More

Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Read More

Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial. Read More

Lete I, Allué J. The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integr Med Insights. Read More

Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. J Altern Complement Med. 2017 Aug;23. Read More

The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review. Read More

Alushi, B., et al. (2021). L-Glycine enhances the function of the adrenal cortex by increasing ACTH secretion: An in vitro study. Biomedicine & Pharmacotherapy, 136, 111280. Glycine – A Small Molecule with a Big Impact on Sleep. Read More

Sivaprakasapillai, B., et al. (2009). Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. Read More

Pinent, M., et al. (2004). Grape-seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology, Read More

Szuster-Ciesielska, A., et al. (2003). Lipopolysaccharide-induced nitric oxide production and cytotoxicity in the N1E-115 cell line is regulated by glutathione. Neurochemistry International. Read More

Kim, N. H., et al. (2021). Ginsenoside Rg3 regulates adrenocortical function via the PKA signaling pathway. Read More

Koh, J. H., et al. (2003). Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin, 26(5), 691-694. Read More

Park, S. H., et al. (2018). Effects of licorice extract on prevention of chronic fatigue syndrome in rats subjected to repeated forced swimming. Read More

Li,S., et al. (2019). Protective effects of glycyrrhizic acid against chronic restraint stress-induced adrenal dysfunction. Food and Chemical Toxicology,123, 480-488. Read More

Tanda, G., et al. (2013). Enhancement of endocannabinoid neurotransmission through enzymatic inhibition of fatty acid amide hydrolase. Journal of Neurochemistry, 124(6),693-704. Read More

Brody, S., et al. (2002). A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Read More

Peters, E. M., et al. (2001). Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. International Journal of Sports Medicine, 22(7), 537-543. Read More

Kennedy, D. O., et al. (2010). Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Read More

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.
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Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Read More

Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia. Read More

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging. Read More

Antidiabetic Action of Alfalfa (Medicago sativa) Leaves Powder on Type II Diabetic Patients. Read More

Evaluation of Medicago sativa L. sproutsas antihyperlipidemic and antihyperglycemic agent. Read More

Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. Read More

Shilajit: A Natural Phytocomplex with Potential Procognitive Activity. Read More

Arginine for mitochondrial oxidative enzymopathy. Read More

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Argininein Patients with Heart Failure. Read More

Anti-aging effects of L-arginine. Read More

Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial. Read More

Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Read More

L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Read More

L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Read More

Effects of carnitine supplementation on liver amino transferase enzymes: A systematic review and meta-analysis of randomized controlled clinical trials. Read More

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Read More

Ameliorative effect of taurine against diabetes and renal-associated disorders. Read More

Effects and Mechanisms of Taurine as a Therapeutic Agent. Read More

Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. Read More

Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Read More

Neuroprotective Effect of Reduced Glutathione on Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial. Read More

A double-blind, randomized and placebo-controlled trial of Saffron (Crocussativus L.) in the treatment of anxiety and depression. Read More

A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocussativus L.) in mothers suffering from mild-to-moderate postpartum depression. Read More

Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. Read More

Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial. Read More

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidantal pha-lipoic acid. A 3-week multicentre randomized controlled trial. Read More

Alpha-lipoicacid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Read More

Double-blind placebo-controlled randomized clinical trial of ginger ( Zingiber officinale Rosc.) addition in migraine acute treatment. Read More

High-DoseAsian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report. Read More

A 14-week randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide(Y-75). Read More

Cognitive function improvement with astaxanthin and tocotrienol intake: a randomized, double-blind, placebo-controlled study. Read More

Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. Read More

A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. Read More

The antioxidant and anti-inflammatory effects of astaxanthin supplementation on the expression of miR-146a and miR-126 in patients with type 2 diabetes mellitus: A randomised, double-blind, placebo-controlled clinical trial. Read More

The efficacy of niacin supplementation in type 2 diabetes patients: Study protocol of a randomized controlled trial. Read More

The Slo-Niacin Trial: A Randomized Double-Blind Placebo-Controlled CrossOver Trial of Extended Release Niacin for Phosphate Lowering in Hemodialysis Patients. Read More

A DoubleBlind, Randomized Cross-Over Trial of Tyrosine Treatment on Cognitive Function and Psychological Parameters in Severe Hospitalized Anorexia Nervosa Patients. Read More

A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men. Read More

Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study v. Read More

Modulatory Effects of Triphala and Manjistha Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Read More

Majewska MD, Bell JA Ascorbic acid protects neurons from injury induced by glutamate and NMDA Neuroreport. (1990 Nov-Dec). Read More

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Niacin: Nicotinic Acid, Nicotinamide, and Inositol Hexanicotinate. Read More

Kamanna VS1, Ganji SH, Kashyap ML The mechanism and mitigation of niacin-induced flushingInt J Clin Pract. (2009 Sep). Read More

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Surjana D1, Halliday GM, Damian DL Role of nicotinamide in DNA damage, mutagenesis, and DNA repairJ Nucleic Acids. (2010 Jul 25). Read More

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Shehadah A1, Chen J, Zacharek A, Cui Y, Ion M, Roberts C,Kapke A, Chopp M Niaspan treatment induces neuroprotection after stroke Neurobiol Dis.(2010 Oct). Read More

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Lavigne PM1, Karas RH The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression J Am Coll Cardiol. (2013 Jan 29). Read More

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Takahashi K, Fukuwatari T, Shibata K Exercise and a High Fat Diet Synergistically Increase the Pantothenic Acid Requirement in RatsJ Nutr Sci Vitaminol (Tokyo). (2015). Read More

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Miller AL The methylation, neurotransmitter, and antioxidant connections between folate and depression Altern Med Rev. (2008). Read More
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Andres E, Serraj K Optimal management of pernicious anemia J Blood Med. (2012). Read More

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Somaye Yosaee, Cain C T Clark, Zahra Keshtkaran, MahkamehAshourpour, Parisa Keshani, Sepideh Soltani Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials Gen HospPsychiatry. (Jan-Feb 2022). Read More

Ali Fallah, Azadeh Mohammad-Hasani, Abasalt Hosseinzadeh Colagar Zinc is an Essential Element for Male Fertility: A Review of Zn Roles inMen's Health, Germination, Sperm Quality, and FertilizationJ Reprod Infertil. (Apr-Jun 2018). Read More

Dorota Skrajnowska, Barbara Bobrowska-Korczak Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms Nutrients. (2019 Sep 22). Read More

Maria Maares, Hajo Haase Zinc and immunity: An essential interrelation Arch Biochem Biophys. (2016 Dec 1). Read More

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Gerry K Schwalfenberg N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with NewTricks)J Nutr Metab. (2021 Jun 9). Read More

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N-acetylcysteine inhibits muscle fatigue in humans. Read More

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Lin Guan, Peng Miao The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials Eur J Pharmacol. (2020 Oct 15). Read More

Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity J Biol Chem. (2008 Nov 21). Read More

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Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI Antioxidant, free radical scavenging and anti-inflammatory effects of aloes in derivatives in Aloe vera Planta Med. (2002 Nov). Read More

Bhalang K, Thunyakitpisal P, Rungsirisatean N Acemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous Ulceration J Altern Complement Med. (2012 Dec 16). Read More

Saito M, Tanaka M, Misawa E, Yamada M, Yamauchi K, Iwatsuki K Aloe vera Gel Extract Attenuates Ethanol-Induced Hepatic Lipid Accumulation by Suppressing the Expression of Lipogenic Genes in MiceBiosci Biotechnol Biochem. (2012 Nov 23). Read More

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