Scientific Research
Evaluation of L-Carnitine Efficacy in the Treatment of Non-Alcoholic Fatty Liver Disease among Diabetic Patients: A Randomized Double Blind Pilot Study. Read More
Alpha-Lipoic Acid (ALA), fatty acid and promising chelating agent for neurological ailments. Read More
The Role of Thiamine in Wilson’s Disease: Possible Genetic and Cellular Signaling Mechanisms. Read More
Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies. Read More
A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders. Read More
Salvatore S, Heuschkel R, Tomlin S, Davies SE, Edwards S, Walker-Smith JA, French I, Murch SH. A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease. Read More
Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Read More
Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Read More
Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial. Read More
Lete I, Allué J. The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integr Med Insights. Read More
Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. J Altern Complement Med. 2017 Aug;23. Read More
The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review. Read More
Alushi, B., et al. (2021). L-Glycine enhances the function of the adrenal cortex by increasing ACTH secretion: An in vitro study. Biomedicine & Pharmacotherapy, 136, 111280. Glycine – A Small Molecule with a Big Impact on Sleep. Read More
Sivaprakasapillai, B., et al. (2009). Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. Read More
Pinent, M., et al. (2004). Grape-seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology, Read More
Szuster-Ciesielska, A., et al. (2003). Lipopolysaccharide-induced nitric oxide production and cytotoxicity in the N1E-115 cell line is regulated by glutathione. Neurochemistry International. Read More
Kim, N. H., et al. (2021). Ginsenoside Rg3 regulates adrenocortical function via the PKA signaling pathway. Read More
Koh, J. H., et al. (2003). Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin, 26(5), 691-694. Read More
Park, S. H., et al. (2018). Effects of licorice extract on prevention of chronic fatigue syndrome in rats subjected to repeated forced swimming. Read More
Li,S., et al. (2019). Protective effects of glycyrrhizic acid against chronic restraint stress-induced adrenal dysfunction. Food and Chemical Toxicology,123, 480-488. Read More
Tanda, G., et al. (2013). Enhancement of endocannabinoid neurotransmission through enzymatic inhibition of fatty acid amide hydrolase. Journal of Neurochemistry, 124(6),693-704. Read More
Brody, S., et al. (2002). A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Read More
Peters, E. M., et al. (2001). Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. International Journal of Sports Medicine, 22(7), 537-543. Read More
Kennedy, D. O., et al. (2010). Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Read More
Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.
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Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Read More
Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia. Read More
Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging. Read More
Antidiabetic Action of Alfalfa (Medicago sativa) Leaves Powder on Type II Diabetic Patients. Read More
Evaluation of Medicago sativa L. sproutsas antihyperlipidemic and antihyperglycemic agent. Read More
Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. Read More
Shilajit: A Natural Phytocomplex with Potential Procognitive Activity. Read More
Arginine for mitochondrial oxidative enzymopathy. Read More
Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Argininein Patients with Heart Failure. Read More
Anti-aging effects of L-arginine. Read More
Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial. Read More
Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Read More
L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Read More
L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Read More
Effects of carnitine supplementation on liver amino transferase enzymes: A systematic review and meta-analysis of randomized controlled clinical trials. Read More
Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Read More
Ameliorative effect of taurine against diabetes and renal-associated disorders. Read More
Effects and Mechanisms of Taurine as a Therapeutic Agent. Read More
Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. Read More
Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Read More
Neuroprotective Effect of Reduced Glutathione on Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial. Read More
A double-blind, randomized and placebo-controlled trial of Saffron (Crocussativus L.) in the treatment of anxiety and depression. Read More
A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocussativus L.) in mothers suffering from mild-to-moderate postpartum depression. Read More
Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. Read More
Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial. Read More
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidantal pha-lipoic acid. A 3-week multicentre randomized controlled trial. Read More
Alpha-lipoicacid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Read More
Double-blind placebo-controlled randomized clinical trial of ginger ( Zingiber officinale Rosc.) addition in migraine acute treatment. Read More
High-DoseAsian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report. Read More
A 14-week randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide(Y-75). Read More
Cognitive function improvement with astaxanthin and tocotrienol intake: a randomized, double-blind, placebo-controlled study. Read More
Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. Read More
A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. Read More
The antioxidant and anti-inflammatory effects of astaxanthin supplementation on the expression of miR-146a and miR-126 in patients with type 2 diabetes mellitus: A randomised, double-blind, placebo-controlled clinical trial. Read More
The efficacy of niacin supplementation in type 2 diabetes patients: Study protocol of a randomized controlled trial. Read More
The Slo-Niacin Trial: A Randomized Double-Blind Placebo-Controlled CrossOver Trial of Extended Release Niacin for Phosphate Lowering in Hemodialysis Patients. Read More
A DoubleBlind, Randomized Cross-Over Trial of Tyrosine Treatment on Cognitive Function and Psychological Parameters in Severe Hospitalized Anorexia Nervosa Patients. Read More
A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men. Read More
Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study v. Read More
Modulatory Effects of Triphala and Manjistha Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Read More
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Hoyumpa AM Jr Mechanisms of thiamin deficiency in chronic alcoholismAm J Clin Nutr. (1980). Read More
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Northrop-Clewes CA, Thurnham DI The discovery and characterization of riboflavin Ann Nutr Metab. (2012). Read More
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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. (1998). Read More
Gariballa S, Forster S, Powers H Riboflavin status in acutely ill patients and response to dietary supplementsJPEN J Parenter Enteral Nutr. (2009 Nov-Dec). Read More
Tavares NR1, Moreira PA, Amaral TF Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly J Nutr Health Aging. (2009 May). Read More
Niacin: Nicotinic Acid, Nicotinamide, and Inositol Hexanicotinate. Read More
Kamanna VS1, Ganji SH, Kashyap ML The mechanism and mitigation of niacin-induced flushingInt J Clin Pract. (2009 Sep). Read More
Wang W1, Basinger A, Neese RA, Shane B, Myong SA, ChristiansenM, Hellerstein MK Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production Am J Physiol Endocrinol Metab. (2001 Mar). Read More
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Shehadah A1, Chen J, Zacharek A, Cui Y, Ion M, Roberts C,Kapke A, Chopp M Niaspan treatment induces neuroprotection after stroke Neurobiol Dis.(2010 Oct). Read More
Chen J1, Cui X, Zacharek A, Jiang H, Roberts C, Zhang C, LuM, Kapke A, Feldkamp CS, Chopp M Niaspan increases angiogenesis and improves functional recovery after stroke Ann Neurol. (2007 Jul). Read More
Lavigne PM1, Karas RH The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression J Am Coll Cardiol. (2013 Jan 29). Read More
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Takahashi K, Fukuwatari T, Shibata K Exercise and a High Fat Diet Synergistically Increase the Pantothenic Acid Requirement in RatsJ Nutr Sci Vitaminol (Tokyo). (2015). Read More
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Spector R Development and Characterization of Pantothenic Acid Transport in Brain J Neurochem. (1986). Read More
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Clayton PT B6-responsive disorders: a model of vitamin dependency J Inherit Metab Dis. (2006 Apr-Jun). Read More
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Miller AL The methylation, neurotransmitter, and antioxidant connections between folate and depression Altern Med Rev. (2008). Read More
Bhargava S, Tyagi SC Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review Mol CellBiochem. (2014). Read More
O'Leary F, Samman S Vitamin B12 in health and disease Nutrients. (2010 Mar). Read More
Dali-Youcef N, Andrès E An update on cobalamin deficiency in adults QJM. (2009 Jan). Read More
Andres E, Serraj K Optimal management of pernicious anemia J Blood Med. (2012). Read More
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Green PH, Alaedini A, Sander HW, Brannagan TH 3rd, Latov N,Chin RL Mechanisms underlying celiac disease and its neurologic manifestations Cell Mol Life Sci. (2005 Apr). Read More
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Schrauzer GN Selenomethionine: a review of its nutritional significance, metabolism and toxicityJ Nutr. (2000 Jul). Read More
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Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Read More
Letavayová L, Vlcková V, Brozmanová J Selenium: from cancer prevention to DNA damage Toxicology. (2006 Oct 3). Read More
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Somaye Yosaee, Cain C T Clark, Zahra Keshtkaran, MahkamehAshourpour, Parisa Keshani, Sepideh Soltani Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials Gen HospPsychiatry. (Jan-Feb 2022). Read More
Ali Fallah, Azadeh Mohammad-Hasani, Abasalt Hosseinzadeh Colagar Zinc is an Essential Element for Male Fertility: A Review of Zn Roles inMen's Health, Germination, Sperm Quality, and FertilizationJ Reprod Infertil. (Apr-Jun 2018). Read More
Dorota Skrajnowska, Barbara Bobrowska-Korczak Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms Nutrients. (2019 Sep 22). Read More
Maria Maares, Hajo Haase Zinc and immunity: An essential interrelation Arch Biochem Biophys. (2016 Dec 1). Read More
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Chad Kerksick, Darryn Willoughby The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stressJ Int Soc Sports Nutr. (2005 Dec 9). Read More
Gerry K Schwalfenberg N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with NewTricks)J Nutr Metab. (2021 Jun 9). Read More
Wang L, Wang Z, Liu J Protective effect of N-acetylcysteine on experimental chronic lead nephrotoxicity in immature female rats Hum Exp Toxicol. (2010 Jul). Read More
Kasperczyk S, Dobrakowski M, Kasperczyk A, Ostałowska A,Birkner E The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead Clin Toxicol (Phila). (2013 Jul). Read More
Schmaal L, Veltman DJ, Nederveen A, van den Brink W,Goudriaan AE N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study Neuro psychopharmacology. (2012 Aug). Read More
N-acetylcysteine inhibits muscle fatigue in humans. Read More
Shurtleff D, Thomas JR, Schrot J, Kowalski K, Harford R Tyrosine reverses a cold-induced working memory deficit in humans Pharmacol Biochem Behav. (1994 Apr). Read More
Yukio Yamori, Takashi Taguchi, Atsumi Hamada, KazuhiroKunimasa, Hideki Mori, Mari Mori Taurine in health and diseases: consistent evidence from experimental and epidemiological studiesJ Biomed Sci.(2010 Aug 24). Read More
Lin Guan, Peng Miao The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials Eur J Pharmacol. (2020 Oct 15). Read More
Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity J Biol Chem. (2008 Nov 21). Read More
Kim Y, Choi Y, Ham H, Jeong HS, Lee J Antioxidant and cytoprotective effects of oligomeric and polymeric procyanidin fractions from defatted grape seed in PC12 cells J Med Food. (2012 May). Read More
Mau JL, Lin HC, Chen CC Antioxidant properties of several medicinal mushrooms J Agric Food Chem. (2002 Oct 9). Read More
Sullivan R, Smith JE, Rowan NJ Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine Perspect Biol Med. (2006 Spring). Read More
Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI Antioxidant, free radical scavenging and anti-inflammatory effects of aloes in derivatives in Aloe vera Planta Med. (2002 Nov). Read More
Bhalang K, Thunyakitpisal P, Rungsirisatean N Acemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous Ulceration J Altern Complement Med. (2012 Dec 16). Read More
Saito M, Tanaka M, Misawa E, Yamada M, Yamauchi K, Iwatsuki K Aloe vera Gel Extract Attenuates Ethanol-Induced Hepatic Lipid Accumulation by Suppressing the Expression of Lipogenic Genes in MiceBiosci Biotechnol Biochem. (2012 Nov 23). Read More
